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- π¬ BetSignalAI NFL & MLBβ September 21st
π¬ BetSignalAI NFL & MLBβ September 21st
4 NFL 3 MLB
π¬ BetSignalAI β NFL Sunday Picks (Sept 21, 2025 β’ CT)
DraftKings lines only β’ One pick per matchup β’ Includes units & βLock It Inβ tickets
π₯ Top Pick of the Day β 1.5u (Strong 4/5)
Tampa Bay Buccaneers β6.5 (β110 DK) vs New York Jets β 12:00 PM CT
Why We Love It: Our sims show the best win/cover combo on the slate at standard juice. Defensive pressure + home field tilt the script.
Lock It In (DK Ticket):
Bet Type: Spread
Pick: Buccaneers β6.5
Odds: β110
Units: 1.5u
Play to: β6.5 (β€ β120). At β7, trim to 1.0u.
β
Pick 2 β 1.5u (Strong 4/5)
Philadelphia Eagles β3.5 (β110 DK) vs Los Angeles Rams β 12:00 PM CT
Why We Love It: Early-down efficiency + trench edge at home. Our fair sits stronger than a field goal.
Lock It In (DK Ticket):
Bet Type: Spread
Pick: Eagles β3.5
Odds: β110
Units: 1.5u
Play to: β3.5 (β€ β115).
β
Pick 3 β 1.0u (Edge 3/5)
Green Bay Packers β9.5 (β110 DK) @ Cleveland Browns β 12:00 PM CT
Why We Love It: Median margin projects near two scores; standard juice keeps EV clean.
Lock It In (DK Ticket):
Bet Type: Spread
Pick: Packers β9.5
Odds: β110
Units: 1.0u
Play to: β9.5 (β€ β115). If β8.5 pops, thatβs an upgrade.
Bonus Ladder β Travis Etienne Rushing (2.0u total) β Texans @ Jaguars, 12:00 PM CT
All rungs DraftKings
0.80u β 60+ yards (+104)
0.45u β 70+ yards (+164)
0.35u β 80+ yards (+247)
0.25u β 90+ yards (+376)
0.15u β 100+ yards (+564)
Play-to guards: 60+ β₯ +100 β’ 70+ β₯ +150 β’ 80+ β₯ +225 β’ 90+ β₯ +325 β’ 100+ β₯ +475
βΎMLBβΎ
π₯ Top Pick of the Day β 1.5u
Milwaukee Brewers β Moneyline (DraftKings)
Opponent: St. Louis Cardinals β’ Start: 1:15 PM CT
Probables: Freddy Peralta (MIL) vs Matthew Liberatore (STL).
Why we love it
SP edge: Peralta over Liberatore; MIL pen grades better late.
Context: Brewers are surging (magic number at 1 after Saturdayβs win). We still rate this a steady ML spot.
π§Ύ DK Ticket
Bet Type: Moneyline
Units: 1.5u
Play to: β150 (if Contreras is confirmed out, keep it to β140)
β Pick 2 β 1.0u
Nationals @ Mets β Over 8.5 β115 (DraftKings)
Start: 12:40 PM CT
Why We Like It
Multiple scoring paths: Both offenses project traffic; late-inning bullpen risk lifts run expectancy.
Number preference: 8.5 gives full-win upside on 9+ (we prefer this to an 8.0 at heavy juice).
Model edge: Total clears our median sim more than the β115 breakeven.
π§Ύ Lock It In (DK Ticket)
Bet Type: Game Total Over 8.5
Odds: β115 (DraftKings)
Units: 1.0u
Play to: β120
β Prop Play β 1.0u
Pete Alonso (Mets) β HRR 3+ (Hits + Runs + RBIs) β plus money only (DraftKings)
Opponent: Washington Nationals β’ Start: 12:40 PM CT
Probables: Sean Manaea (NYM) vs Jake Irvin (WSH).
Why we like it
Multiple paths to 3 HRR (1H+1R+1RBI, 2H+1R, or a HR = 4 HRR).
Matchup fit: Alonsoβs RBI/run equity is strong vs Irvin with NYM favored at home.
π§Ύ DK Ticket
Bet Type: HRR 3+
Units: 1.0u
Price rule: Take at +100 or better (pass if it slips below even).
Contingency: If Alonso doesnβt start, pivot to Francisco Lindor β HRR 3+ +105 or better.
π Todayβs Card (CT)
Brewers ML β 1.5u β 1:15 PM @ Cardinals.
Nationals/Mets over 8.5 β 12:40 pm
Pete Alonso HRR 3+ β 1.0u β 12:40 PM vs Nationals.
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CT times verified from team/league pages; stick to the Play to lines if DraftKings moves.